Rapid signaling of estrogen to WAVE1 and moesin controls neuronal spine formation via the actin cytoskeleton.

@article{Sanchez2009RapidSO,
  title={Rapid signaling of estrogen to WAVE1 and moesin controls neuronal spine formation via the actin cytoskeleton.},
  author={Angel Mat{\'i}as Sanchez and Marina In{\'e}s Flamini and Xiao-Dong Fu and Paolo Mannella and Maria Silvia Giretti and Lorenzo Goglia and Andrea Riccardo Genazzani and Tommaso Simoncini},
  journal={Molecular endocrinology},
  year={2009},
  volume={23 8},
  pages={1193-202}
}
Estrogens are important regulators of neuronal cell morphology, and this is thought to be critical for gender-specific differences in brain function and dysfunction. Dendritic spine formation is dependent on actin remodeling by the WASP-family verprolin homologous (WAVE1) protein, which controls actin polymerization through the actin-related protein (Arp)-2/3 complex. Emerging evidence indicates that estrogens are effective regulators of the actin cytoskeleton in various cell types via rapid… CONTINUE READING

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In parallel , E2 recruits a Galpha(13)-dependent pathway to RhoA and ROCK-2 , leading to activation of actin remodeling via the actin - binding protein , moesin .
In parallel , E2 recruits a Galpha(13)-dependent pathway to RhoA and ROCK-2 , leading to activation of actin remodeling via the actin - binding protein , moesin .
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