Rapid signaling at the plasma membrane by a nuclear receptor for thyroid hormone.

@article{Storey2006RapidSA,
  title={Rapid signaling at the plasma membrane by a nuclear receptor for thyroid hormone.},
  author={Nina M Storey and Saverio Gentile and Hemayet Ullah and Angela Russo and Michelle J Muessel and Christian Erxleben and David Lee Armstrong},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 13},
  pages={5197-201}
}
Many nuclear hormones have physiological effects that are too rapid to be explained by changes in gene expression and are often attributed to unidentified or novel G protein-coupled receptors. Thyroid hormone is essential for normal human brain development, but the molecular mechanisms responsible for its effects remain to be identified. Here, we present direct molecular evidence for potassium channel stimulation in a rat pituitary cell line (GH(4)C(1)) by a nuclear receptor for thyroid hormone… CONTINUE READING