Rapid screening of commercially available herbal products for the inhibition of major human hepatic cytochrome P450 enzymes using the N-in-one cocktail.

@article{Sevior2010RapidSO,
  title={Rapid screening of commercially available herbal products for the inhibition of major human hepatic cytochrome P450 enzymes using the N-in-one cocktail.},
  author={Danielle K Sevior and Juho Hokkanen and Ari Tolonen and Khaled Abass and Larissa Tursas and Olavi Pelkonen and Jorma T. Ahokas},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={2010},
  volume={40 4},
  pages={
          245-54
        }
}
Self-administration of complementary products concurrently with conventional medication is increasingly common. The potential for cytochrome P450 (CYP) inhibition requires investigation. The N-in-one assay with ten probe substrates for nine CYPs was used with human liver microsomes to investigate ten products. CYP inhibition was measured in a single liquid chromatography-tandem mass spectrometry (LC/MS-MS) analysis. Estimated IC(50)-values were determined for the extracts that produced… CONTINUE READING
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