Rapid reversible changes in dendritic spine structure in vivo gated by the degree of ischemia.

@article{Zhang2005RapidRC,
  title={Rapid reversible changes in dendritic spine structure in vivo gated by the degree of ischemia.},
  author={Shengxiang Zhang and Jamie Boyd and Kerry Delaney and Timothy H. Murphy},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2005},
  volume={25 22},
  pages={5333-8}
}
Current therapeutic windows for effective application of thrombolytic agents are within 3-6 h of stroke. Although treatment can improve outcome, it is unclear what happens to synaptic fine structure during this critical period in vivo. The relationship between microcirculation and dendritic spine structure was determined in mouse somatosensory neurons during stroke. Spines were, on average, 13 mum from a capillary and were supplied by approximately 100 red blood cells per second. Moderate… CONTINUE READING
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