Rapid release of entrapped contents from multi-functionalizable, surface cross-linked micelles upon different stimulation.

@article{Zhang2010RapidRO,
  title={Rapid release of entrapped contents from multi-functionalizable, surface cross-linked micelles upon different stimulation.},
  author={Shiyong Zhang and Yan Zhao},
  journal={Journal of the American Chemical Society},
  year={2010},
  volume={132 31},
  pages={
          10642-4
        }
}
  • Shiyong Zhang, Yan Zhao
  • Published 16 July 2010
  • Biology, Chemistry, Materials Science
  • Journal of the American Chemical Society
Hydrophobic guests such as pyrene could be readily trapped inside the micelles of an alkynylated surfactant in the presence of an azide-functionalized cross-linker using the click reaction. The cross-linker was designed to contain cleavable bonds such as geminal diol, disulfide, and acetal. The resulting pyrene-containing water-soluble nanoparticle was under electrostatic stress when diluted below the CMC of the surfactant. Extremely rapid (<1 min) release of the hydrophobic content was… 
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References

SHOWING 1-10 OF 20 REFERENCES
Degradable disulfide core-cross-linked micelles as a drug delivery system prepared from vinyl functionalized nucleosides via the RAFT process.
TLDR
Cytotoxicity tests confirmed the biocompatibility of the polymers and the residues after reduction, and core-shell nanoparticles, which can degrade under reductive conditions, were found.
Facile Synthesis of Multivalent Water-Soluble Organic Nanoparticles via ``Surface Clicking'' of Alkynylated Surfactant Micelles
TLDR
Two of the most widely used scaffolds in multivalency are dendrimers and gold nanoparticles protected with functionalized thiols.
Disulfide-cross-linked PEG-poly(amino acid)s copolymer micelles for glutathione-mediated intracellular drug delivery.
We report biocompatible, cell-permeable core-shell-corona polymer micelles bearing glutathione-cleavable shell cross-links, which allow the facilitated release of entrapped anticancer drugs at…
Intelligent polymeric micelles from functional poly(ethylene glycol)-poly(amino acid) block copolymers.
Block copolymer micelles as vehicles for hydrophobic drugs
The neuroleptic activity of haloperidol increases after its solubilization in surfactant micelles
Thermogelling poly(ethylene oxide-b-propylene oxide-b-ethylene oxide) disulfide multiblock copolymer as a thiol-sensitive degradable polymer.
TLDR
The hydrophobic dye solubilization and dynamic light scattering of the polymer aqueous solution suggest that the poly(ethylene oxide-b-propylene oxide- b- methylene oxide)s undergo unimer (3 nm) to micelle (12 nm) transition, whereas the disulfide multiblock copolymers undergoing unimer to aggregated polymer transition as the temperature increases.
Environmental effects on vibronic band intensities in pyrene monomer fluorescence and their application in studies of micellar systems
The fluorescence intensities for various vibronic fine structures in the pyrene monomer fluorescence show strong solvent dependence. In the presence of polar solvents, there is a significant…
Extracellular acidification induces human neutrophil activation.
TLDR
The notion that extracellular acidosis may intensify acute inflammatory responses by inducing neutrophil activation as well as by delaying spontaneous apoptosis and extending neutrophils functional lifespan is supported.
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
...
...