Rapid regulation of thyroid sodium-iodide symporter activity by thyrotrophin and iodine.

@article{Ferreira2005RapidRO,
  title={Rapid regulation of thyroid sodium-iodide symporter activity by thyrotrophin and iodine.},
  author={Andrea Claudia Freitas Ferreira and L{\'i}via Peixoto Moreira Lima and Renata Lopes Araujo and Glaucia M{\"u}ller and Renata Lacerda Prata Rocha and Doris Rosenthal and Denise Pires de Carvalho},
  journal={The Journal of endocrinology},
  year={2005},
  volume={184 1},
  pages={
          69-76
        }
}
Transport of iodide into thyrocytes, a fundamental step in thyroid hormone biosynthesis, depends on the presence of the sodium-iodide symporter (NIS). The importance of the NIS for diagnosis and treatment of diseases has raised several questions about its physiological control. The goal of this study was to evaluate the influence of thyroid iodine content on NIS regulation by thyrotrophin (TSH) in vivo. We showed that 15-min thyroid radioiodine uptake can be a reliable measurement of NIS… CONTINUE READING

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