Rapid regulation of the 'second inward current' by intracellular calcium in isolated rat and ferret ventricular myocytes.

@article{Boyett1988RapidRO,
  title={Rapid regulation of the 'second inward current' by intracellular calcium in isolated rat and ferret ventricular myocytes.},
  author={Mark R. Boyett and Mark Stephen Kirby and Clive H Orchard},
  journal={The Journal of physiology},
  year={1988},
  volume={407},
  pages={
          77-102
        }
}
1. Single cells were isolated from the ventricles of ferret and rat hearts. Cells were voltage clamped using a single conventional microelectrode. Membrane voltage, membrane currents and cell length were monitored. 2. The current elicited by decreasing the membrane potential from a holding potential of -40 or -45 mV to potentials more positive than -20 mV was abolished by D600, by Cd2+ and by removal of Ca2+ from the cell superfusate. This current activated within 20 ms and inactivated over… CONTINUE READING

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