Rapid regulation of telomere length is mediated by poly(ADP-ribose) polymerase-1

@inproceedings{Beneke2008RapidRO,
  title={Rapid regulation of telomere length is mediated by poly(ADP-ribose) polymerase-1},
  author={Sascha Beneke and Odile Cohausz and Maria Malanga and Petra Boukamp and Felix R. Althaus and Alexander B{\"u}rkle},
  booktitle={Nucleic acids research},
  year={2008}
}
Shelterin/telosome is a multi-protein complex at mammalian telomeres, anchored to the double-stranded region by the telomeric-repeat binding factors-1 and -2. In vitro modification of these proteins by poly(ADP-ribosyl)ation through poly(ADP-ribose) polymerases-5 (tankyrases) and -1/-2, respectively, impairs binding. Thereafter, at least telomeric-repeat binding factor-1 is degraded by the proteasome. We show that pharmacological inhibition of poly(ADP-ribose) polymerase activity in cells from… CONTINUE READING

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