Rapid regulation of telomere length is mediated by poly(ADP-ribose) polymerase-1

  title={Rapid regulation of telomere length is mediated by poly(ADP-ribose) polymerase-1},
  author={Sascha Beneke and Odile Cohausz and Maria Malanga and Petra Boukamp and Felix R. Althaus and Alexander B{\"u}rkle},
  booktitle={Nucleic acids research},
Shelterin/telosome is a multi-protein complex at mammalian telomeres, anchored to the double-stranded region by the telomeric-repeat binding factors-1 and -2. In vitro modification of these proteins by poly(ADP-ribosyl)ation through poly(ADP-ribose) polymerases-5 (tankyrases) and -1/-2, respectively, impairs binding. Thereafter, at least telomeric-repeat binding factor-1 is degraded by the proteasome. We show that pharmacological inhibition of poly(ADP-ribose) polymerase activity in cells from… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 38 extracted citations

CRISPR-Cas9 Mediated Telomere Removal Leads to Mitochondrial Stress and Protein Aggregation

International journal of molecular sciences • 2017
View 6 Excerpts
Highly Influenced

PARP, transcription and chromatin modeling.

Seminars in cell & developmental biology • 2017
View 2 Excerpts


Publications referenced by this paper.
Showing 1-10 of 83 references

Similar Papers

Loading similar papers…