Rapid regulation of c-myc protooncogene expression by progesterone in the avian oviduct.

@article{Fink1988RapidRO,
  title={Rapid regulation of c-myc protooncogene expression by progesterone in the avian oviduct.},
  author={Kyle Fink and Eric D. Wieben and Gayle E Woloschak and Thomas C. Spelsberg},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1988},
  volume={85 6},
  pages={
          1796-800
        }
}
The mRNA levels of genes known to be regulated by sex steroids are not altered until 1 hr or longer after steroid treatment, although the steroid receptor complexes are bound to nuclear acceptor sites within 5 min. In a search for early regulation of gene transcription, total chick oviduct RNA was isolated at various times after injection (i.p.) of progesterone and analyzed for c-myc expression. Levels of c-myc mRNA began to decrease in response to progesterone by 10 min after injection. The… CONTINUE READING
BETA