Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: Evidence for membrane cycling from Golgi to ER

@article{LippincottSchwartz1989RapidRO,
  title={Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: Evidence for membrane cycling from Golgi to ER},
  author={Jennifer Lippincott-Schwartz and Lydia C. Yuan and Juan S Bonifacino and Richard D. Klausner},
  journal={Cell},
  year={1989},
  volume={56},
  pages={801-813}
}
In cells treated with brefeldin A (BFA), movement of newly synthesized membrane proteins from the endoplasmic reticulum (ER) to the Golgi apparatus was blocked. Surprisingly, the glycoproteins retained in the ER were rapidly processed by cis/medial Golgi enzymes but not by trans Golgi enzymes. An explanation for these observations was provided from morphological studies at both the light and electron microscopic levels using markers for the cis/medial and trans Golgi. They revealed a rapid and… CONTINUE READING
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