Rapid recycling of ClC-2 chloride channels between plasma membrane and endosomes: role of a tyrosine endocytosis motif in surface retrieval.

@article{Cornejo2009RapidRO,
  title={Rapid recycling of ClC-2 chloride channels between plasma membrane and endosomes: role of a tyrosine endocytosis motif in surface retrieval.},
  author={Isabel Cornejo and Mar{\'i}a Isabel Niemeyer and Leandro Z{\'u}{\~n}iga and Yamil R Yusef and Francisco V Sep{\'u}lveda and L. Pablo Cid},
  journal={Journal of cellular physiology},
  year={2009},
  volume={221 3},
  pages={
          650-7
        }
}
ClC-2 chloride channel is present in the brain and some transporting epithelia where its function is poorly understood. We have now demonstrated that the surface channels are rapidly internalised and approximately the 70% of the surface membrane protein recycles after 4- to 8-min internalisation. Endocytosis of ClC-2 was dependent upon tyrosine 179 located within an endocytic motif. Rapid recycling accompanied by an even faster internalisation could account for the abundant presence of ClC-2 in… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-8 OF 8 CITATIONS

Research and progress on ClC-2

  • Molecular medicine reports
  • 2017
VIEW 3 EXCERPTS
CITES BACKGROUND

Chloride Channelopathies of ClC-2

  • International journal of molecular sciences
  • 2013
VIEW 1 EXCERPT
CITES BACKGROUND