Rapid recruitment of innate immunity regulates variation of intracellular pathogen resistance in Drosophila.

@article{Okado2009RapidRO,
  title={Rapid recruitment of innate immunity regulates variation of intracellular pathogen resistance in Drosophila.},
  author={Kiyoshi Okado and Naoaki Shinzawa and Hiroka Aonuma and Bryce Nelson and Shinya Fukumoto and Kozo Fujisaki and Shin-ichiro Kawazu and Hirotaka Kanuka},
  journal={Biochemical and biophysical research communications},
  year={2009},
  volume={379 1},
  pages={
          6-10
        }
}
Genetic variation in susceptibility to pathogens is a central concern both to medicine and agriculture and to the evolution of animals. Here, we have investigated the link between such natural genetic variation and the immune response in wild-type Drosophila melanogaster, a major model organism for immunological research. We found that within nine wild-type strains, different Drosophila genotypes show wide-ranging variation in their ability to survive infection from the pathogenic bacteria… CONTINUE READING

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