Rapid radial transport of methyl nicotinate in the dermis

@article{Guy1982RapidRT,
  title={Rapid radial transport of methyl nicotinate in the dermis},
  author={Richard Guy and Howard Ira Maibach},
  journal={Archives of Dermatological Research},
  year={1982},
  volume={273},
  pages={91-95}
}
Topical application of a sufficiently concentrated aqueous solution of methyl nicotinate elicits within minutes an erythematous, vasodilatory response in humans. In this study the radial increase of the erythematous area visible in the skin has been followed as a function of solution application time and methyl nicotinate concentration. Because of the nature of the physiological response, the observations are interpreted in terms of the dermal movement of the drug. The rate of radial spread was… CONTINUE READING

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