Rapid quantification of malondialdehyde in plasma by high performance liquid chromatography-visible detection.

@article{Grotto2007RapidQO,
  title={Rapid quantification of malondialdehyde in plasma by high performance liquid chromatography-visible detection.},
  author={Denise Grotto and Lucas D Santa Maria and Silvana Peterini Boeira and Juliana Valentini and Mariele Feiffer Char{\~a}o and Ana Maria Moro and Paulo C{\'i}cero do Nascimento and Valdeci J Pomblum and Solange Cristina Garcia},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={2007},
  volume={43 2},
  pages={619-24}
}
BACKGROUND Malondialdehyde (MDA) is one of the better-known secondary products of lipid peroxidation, and it is widely used as an indicator of cellular injury. The employment of the thiobarbituric acid reactive substances (TBARS) technique to measure MDA has received criticism over the years because of its lack of specificity. Thus, a specific and reliable method for MDA determination in plasma by high performance liquid chromatographic (HPLC)-VIS was validated; alkaline hydrolysis, n-butanol… CONTINUE READING

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