Rapid proliferation of calcitonin gene-related peptide-immunoreactive nerves during healing of rat tibial fracture suggests neural involvement in bone growth and remodelling.

@article{Hukkanen1993RapidPO,
  title={Rapid proliferation of calcitonin gene-related peptide-immunoreactive nerves during healing of rat tibial fracture suggests neural involvement in bone growth and remodelling.},
  author={Mika V J Hukkanen and Yrj{\"o} T. Konttinen and Seppo Santavirta and Pekka Paavolainen and Xialong Gu and Giorgio Terenghi and Julia M P Polak},
  journal={Neuroscience},
  year={1993},
  volume={54 4},
  pages={969-79}
}
The nervous system may be actively involved in bone repair and in remodelling of callous tissue in bone fractures, as well as in the regulation of nociceptive impulses from the site of the trauma. The aim of this study was to assess the distribution and nature of the periosteal innervation of normal control bone and during bone healing subsequent to fracture of rat tibiae at seven, 14 and 21 days after experimental fracture using immunocytochemistry and image analysis quantification of the… CONTINUE READING
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