Rapid procoagulant phosphatidylserine exposure relies on high cytosolic calcium rather than on mitochondrial depolarization.

@article{Arachiche2009RapidPP,
  title={Rapid procoagulant phosphatidylserine exposure relies on high cytosolic calcium rather than on mitochondrial depolarization.},
  author={Amal Arachiche and Dani{\`e}le Kerbiriou-Nabias and Isabelle Garcin and T. Letellier and Jeanne Dachary-Prigent},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2009},
  volume={29 11},
  pages={1883-9}
}
OBJECTIVE Relationships between intracellular Ca(2+) concentration ([Ca(2+)](cyt)) and apoptotic events, such as mitochondrial depolarization (DeltaPsim loss) and Bcl-2 and Bad phosphorylation, were analyzed in platelets and Jurkat cells in relation to rapid procoagulant phosphatidylserine (PS) exposure. METHODS AND RESULTS Platelets were stimulated with A23187, thapsigargin (TG) and thrombin plus convulxin (Thr/Cvx), and Jurkat cells with ionomycin, in the presence or absence of cyclosporin… CONTINUE READING
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