Rapid prenatal aneuploidy screening by fluorescence in situ hybridization (FISH).

@article{Weise2008RapidPA,
  title={Rapid prenatal aneuploidy screening by fluorescence in situ hybridization (FISH).},
  author={Anja Weise and Thomas Liehr},
  journal={Methods in molecular biology},
  year={2008},
  volume={444},
  pages={39-47}
}
The most common aneuploidies in prenatal diagnostics of the second trimenon are trisomies of chromosomes 13, 18, and 21 and gonosomal abnormalities. To detect these trisomies as quickly as possible after amniocentesis, besides using polymerase chain reaction, fluorescence in situ hybridization (FISH), applying corresponding centromeric or locus-specific probes, is the method of choice. Results of a rapid prenatal aneuploidy screening in uncultured amniocytes by using FISH are available within… CONTINUE READING