Rapid paracellular transmigration of Campylobacter jejuni across polarized epithelial cells without affecting TER: role of proteolytic-active HtrA cleaving E-cadherin but not fibronectin

@inproceedings{Boehm2012RapidPT,
  title={Rapid paracellular transmigration of Campylobacter jejuni across polarized epithelial cells without affecting TER: role of proteolytic-active HtrA cleaving E-cadherin but not fibronectin},
  author={Manja Boehm and Benjamin Hoy and Manfred Rohde and Nicole Tegtmeyer and Kristoffer T. B{\ae}k and Omar A. Oyarzabal and Lone Br{\o}ndsted and Silja Wessler and Steffen Backert},
  booktitle={Gut pathogens},
  year={2012}
}
BackgroundCampylobacter jejuni is one of the most important bacterial pathogens causing food-borne illness worldwide. Crossing the intestinal epithelial barrier and host cell entry by C. jejuni is considered the primary reason of damage to the intestinal tissue, but the molecular mechanisms as well as major bacterial and host cell factors involved in this process are still widely unclear.ResultsIn the present study, we characterized the serine protease HtrA (high-temperature requirement A) of C… CONTINUE READING
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