Rapid optical control of nociception with an ion channel photoswitch

  title={Rapid optical control of nociception with an ion channel photoswitch},
  author={Alexandre Mourot and Timm Fehrentz and Yves Le Feuvre and Caleb M. Smith and Christian Herold and Deniz Dalkara and Fr{\'e}d{\'e}ric Nagy and Dirk Trauner and Richard H. Kramer},
  booktitle={Nature Methods},
Local anesthetics effectively suppress pain sensation, but most of these compounds act nonselectively, inhibiting activity of all neurons. Moreover, their actions abate slowly, preventing precise spatial and temporal control of nociception. We developed a photoisomerizable molecule, quaternary ammonium–azobenzene–quaternary ammonium (QAQ), that enables rapid and selective optical control of nociception. QAQ is membrane-impermeant and has no effect on most cells, but it infiltrates pain-sensing… CONTINUE READING
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