Rapid ocular angiogenic control via naked DNA delivery to cornea.

  title={Rapid ocular angiogenic control via naked DNA delivery to cornea.},
  author={Stephen U Stechschulte and Antonia Maria Joussen and Horst A von Recum and Vasiliki Poulaki and Yasufumi Moromizato and Jie Yuan and Robert J D'Amato and C Kuo and Anthony P. Adamis},
  journal={Investigative ophthalmology & visual science},
  volume={42 9},
PURPOSE To determine the efficacy and safety of naked plasmid gene therapy to the corneal stroma and epithelium. METHODS Naked plasmid DNA was injected under pressure into the cornea of mice. The expression of genes coding for beta galactosidase (beta-gal), enhanced green fluorescent protein (EGFP), vascular endothelial growth factor (VEGF), and soluble Flt-1 (s-Flt) was recorded and measured with regard to dose, time course, and bioactivity. RESULTS LacZ gene expression of the protein beta… CONTINUE READING
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