Rapid nuclear responses to target-derived neurotrophins require retrograde transport of ligand-receptor complex.

@article{Watson1999RapidNR,
  title={Rapid nuclear responses to target-derived neurotrophins require retrograde transport of ligand-receptor complex.},
  author={Fiona L. Watson and Heather M. Heerssen and D B Moheban and Michael Z. Lin and Claire Marie-Elisabeth Sauvageot and Anita Bhattacharyya and Scott L. Pomeroy and Rosalind A. Segal},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1999},
  volume={19 18},
  pages={7889-900}
}
Target-derived neurotrophins initiate signals that begin at nerve terminals and cross long distances to reach the cell bodies and regulate gene expression. Neurotrophin receptors, Trks, themselves serve as retrograde signal carriers. However, it is not yet known whether the retrograde propagation of Trk activation reflects movement of Trk receptors from neurites to cell bodies or reflects serial activation of stationary Trk molecules. Here, we show that neurotrophins selectively applied to… CONTINUE READING