Rapid multi-analyte quantification of benzophenone, 4-methylbenzophenone and related derivatives from paperboard food packaging

  title={Rapid multi-analyte quantification of benzophenone, 4-methylbenzophenone and related derivatives from paperboard food packaging},
  author={Riitta Koivikko and Sara Pastorelli and Ana Rodr{\'i}guez-Bernaldo de Quir{\'o}s and Rafael Paseiro-Cerrato and Perfecto Paseiro-Losada and Catherine Simoneau},
  journal={Food Additives \& Contaminants: Part A},
  pages={1478 - 1486}
Photo-initiators are used in printing inks hardened with UV light and one of the most commonly used photo-initiators is benzophenone (BP). Recent notifications under the Rapid Alert System for Food and Feed have shown migration of 4-methylbenzophenone (4-MBP) from packaging into cereals. A specific migration limit exists for BP of 0.6 mg kg−1 for its use as an additive in plastics. There is no specific European legislation covering cardboard boxes and/or printing inks for food contact use… 
Benzophenone UV-Photoinitiators Used in Food Packaging: Potential for Human Exposure and Health Risk Considerations
Chemicals that are used in ultraviolet (UV) print inks include benzophenone-based UV-photoinitiators used in printing the surface of food packaging, especially printed cartonboard. Since these inks
Cumulative Dietary Risk Assessment of Benzophenone-Type Photoinitiators from Packaged Foodstuffs
Photoinitiators used in ultraviolet-cured ink may migrate from food packaging materials into food products. Therefore, we conducted a dietary risk assessment of exposure to benzophenone (BP)-type
Development and Validation of a Rapid Method for Identification and Quantitation of Benzophenone and Related 17 Derivatives in Paper and Cardboard Packaging Materials by Gas Chromatography–Mass Spectrometry
Benzophenone (BP) and its derivates are photoinitiators widely used in food packaging to cure inks or lacquers with ultraviolet light on cardboards and papers. Although there is no specific European
Development and validation of an HPLC method for the determination of endocrine disruptors bisphenol A and benzophenone in thermochromic printing inks
ABSTRACT The endocrine disruptors bisphenol A (BPA) and benzophenone (BFN) could be important ingredients in thermochromic printing inks in significant amounts. Due to patent protection and use of
Survey on the occurrence of photo-initiators and amine synergists in cartonboard packaging on the German market and their migration into the packaged foodstuffs
Differences in transfer rates for HCHPK, BP and MBP from several packagings into food and Tenax®, respectively, lead to the assumption that both the food matrix as well as the extent of cross-linking of the printing ink during curing may have an influence on the level of migration.
Identification of print-related contaminants in food packaging
  • M. A. Lago, L. Ackerman
  • Chemistry, Medicine
    Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment
  • 2016
The identities of 16 PIs, seven known scission products and five probable PI degradants were confirmed, most showing signs of set-off, and at least five are novel print contaminants such as 4-morpholin-4-yl-benzaldehyde or 3-phenyl-2-benZofuran-1(3H)-one.
Simultaneous chromatographic analysis of photoinitiators and amine synergists in food contact materials
High-performance liquid chromatography with diode-array detection (HPLC–DAD) has been used for analysis of PIs and amine synergists in food packaging and was validated for linearity, repeatability, and limits of detection and quantification.
Migration of Photoinitiators in Food Packaging: A Review
The use of polymeric multifunctional photoinitiators is concluded as the best option for ultraviolet curing inks and varnishes to print food packaging because they have higher molecular weight together with fewer and lower volatility photodecomposition byproducts and a higher probability of being bound into the cured polymer matrix.
Identification of Benzophenone Analogs in Rice Cereal through Fast Pesticide Extraction and Ultrahigh-Performance Liquid Chromatography–Tandem Mass Spectrometry
A fast, robust, and sensitive analytical method was developed and validated for the simultaneous identification of benzophenone (BP) and nine BP analogs (BP-1, BP-2, BP-3, BP-8,
Multi-analyte methods for the detection of photoinitiators and amine synergists in food contact materials and foodstuffs – Part I: HPLC-DAD screening of materials
  • T. Jung, C. Browatzki, T. Simat
  • Chemistry
    Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment
  • 2014
A HPLC-DAD method suitable for the screening of food contact materials for a total of 63 monomeric and polymeric photoinitiators and amine synergists with adequate limits of detection was developed.


Benzophenone in cartonboard packaging materials and the factors that influence its migration into food
When the mass fraction of benzophenone migration was calculated for the different contact and storage regimes involved, the attenuation effects of indirect contact and of low temperature storage were cumulative and there was a sixfold reduction in migration for indirect contact compared with direct contact, a six fold reduction for chilled/frozen storage compared with ambient storage, and 40-fold reduction for the two contact conditions combined.
Study of the migration of benzophenone from printed paperboard packages to cakes through different plastic films
Benzophenone is one of the most commonly used photoinitiators, which are mostly used in UV-cured inks for which drying times are much shorter than for conventional solvent or water-based coatings.
Development of an analytical method for the determination of photoinitiators used for food packaging materials with potential to migrate into milk.
The aim of the present work was to develop a multimethod for the analysis of 6 photoinitiators in milk to carry out analytical methods for the detection of those compounds in food as potential migrants from packaging.
Development of a multimethod for the determination of photoinitiators in beverage packaging.
A reverse-phase high performance liquid chromatography method with UV detection was developed to quantify the 6 selected photoionitiators and recovery of all photoinitiators from orange juice was satisfactory.
Determination of isopropyl thioxanthone (ITX) in fruit juices by pressurized liquid extraction and liquid chromatography-mass spectrometry.
The first report of a positive mass spectrometric identification and quantification of ITX in fruit juice samples packed in TetraPack is reported, enabling it to be the method of choice for risk assessment and monitoring.
Analysis of food packaging UV inks for chemicals with potential to migrate into food simulants
The paper presents chromatographic methods to ascertain the level of ink ingredients potentially available to migrate into food simulants (migration tests) and GC/MS was employed to quantify the levels of photo-initiators or acrylic esters (acrylates).
Toxicity testing and chemical analyses of recycled fibre-based paper for food contact
This pilot study compared paper of different qualities as food-contact materials and to perform a preliminary evaluation of their suitability, from a safety point of view, and to evaluate the use of different in vitro toxicity tests for screening of paper and board.
A systematic study on the stability of UV ink photoinitiators in food simulants using GC
Several studies have been published on the stability of plastic monomers and additives in food simulants. However, there are practically no published results about the stability of ink components in
Migration of photoinitiators by gas phase into dry foods.
High migration level was found to correlate with both the porosity and the fat content of the cake and the kinetics of migration of the photoinitiators from the additive enriched wax into the cake were studied under accelerated conditions.