Rapid molecular response during early induction chemotherapy predicts a good outcome in childhood acute lymphoblastic leukemia.

@article{PanzerGrmayer2000RapidMR,
  title={Rapid molecular response during early induction chemotherapy predicts a good outcome in childhood acute lymphoblastic leukemia.},
  author={Eva-Renate Panzer-Gr{\"u}mayer and Michael A. E. Schneider and Simon Panzer and Karin Fasching and Helmut Gadner},
  journal={Blood},
  year={2000},
  volume={95 3},
  pages={
          790-4
        }
}
Early response to therapy is an independent prognostic factor in childhood acute lymphoblastic leukemia. Although most patients have rapid early responses, as detected by morphology, 15% to 20% of patients have relapses. The authors evaluated residual disease by molecular methods on day 15 of minimal residual disease (MRD) therapy and compared these data with their recently established MRD-based risk stratification, defined by MRD levels 5 weeks after induction treatment and before… CONTINUE READING

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