Rapid modulation of synaptic plasticity by estrogens as well as endocrine disrupters in hippocampal neurons

@article{OgiueIkeda2008RapidMO,
  title={Rapid modulation of synaptic plasticity by estrogens as well as endocrine disrupters in hippocampal neurons},
  author={Mari Ogiue-Ikeda and Nobuaki Tanabe and Hideo Mukai and Yasushi Hojo and Gen Murakami and Tomokazu Tsurugizawa and Norio Takata and Tetsuya Kimoto and S Kawato},
  journal={Brain Research Reviews},
  year={2008},
  volume={57},
  pages={363-375}
}

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References

SHOWING 1-10 OF 82 REFERENCES
Rapid modulation of long‐term depression and spinogenesis via synaptic estrogen receptors in hippocampal principal neurons
TLDR
Two types of independent synaptic plasticity, long‐term depression and spinogenesis, were investigated, in response to 17β‐estradiol and agonists of estrogen receptors using hippocampal slices from adult male rats, and it was demonstrated that estradiol rapidly enhanced LTD not only in CA1 but also in CA3 and dentate gyrus.
Estrogen induces rapid decrease in dendritic thorns of CA3 pyramidal neurons in adult male rat hippocampus.
Comparison between basal and apical dendritic spines in estrogen-induced rapid spinogenesis of CA1 principal neurons in the adult hippocampus.
Hippocampal Synapses Depend on Hippocampal Estrogen Synthesis
TLDR
The results point to an essential role of endogenous hippocampal estrogen synthesis in the maintenance of hippocampal spine synapses as well as the synthesis of synaptic proteins.
Rapid spinogenesis of pyramidal neurons induced by activation of glucocorticoid receptors in adult male rat hippocampus.
17beta-estradiol enhances NMDA receptor-mediated EPSPs and long-term potentiation.
TLDR
In vitro hippocampal slices from 2-mo-old Sprague-Dawley male rats were used to demonstrate that estrogen enhances NMDA receptor-mediated currents and promotes an enhancement of LTP magnitude.
17β-estradiol suppresses expression of long-term depression in aged rats
Rapid Action of 17β-Estradiol on Kainate-Induced Currents in Hippocampal Neurons Lacking Intracellular Estrogen Receptors.
TLDR
It is reported that the rapid action of 17β-estradiol is independent from the classical ER activation in the modulation of membrane excitability and could be mimicked by 8-bromo-cAMP, an activator of protein kinase A.
Rapid action of 17beta-estradiol on kainate-induced currents in hippocampal neurons lacking intracellular estrogen receptors.
TLDR
It is reported that the rapid action of 17beta-estradiol is independent from the classical ER activation in the modulation of membrane excitability, and evidence that a distinct estrogen-binding site exists is provided, which appears to be coupled to alpha-amino-3-hydroxyl-5-methyl-4-isoxazole proprionic acid/kainate receptors by a cAMP-dependent phosphorylation process.
Estrogen Actions Throughout the Brain
Besides affecting the hypothalamus and other brain areas related to reproduction, ovarian steroids have widespread effects throughout the brain, on serotonin pathways, catecholaminergic neurons, and
...
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