Rapid modulation of synaptic plasticity by estrogens as well as endocrine disrupters in hippocampal neurons

  title={Rapid modulation of synaptic plasticity by estrogens as well as endocrine disrupters in hippocampal neurons},
  author={M. Ogiue-Ikeda and N. Tanabe and H. Mukai and Y. Hojo and S. Kawato},
  journal={Brain Research Reviews},
  • M. Ogiue-Ikeda, N. Tanabe, +2 authors S. Kawato
  • Published 2008
  • Medicine, Biology
  • Brain Research Reviews
  • Estrogen modulates memory-related synaptic plasticity not only slowly but also rapidly in the hippocampus. However, molecular mechanisms of the rapid action are yet largely unknown. We here describe rapid modulation of representative synaptic plasticity, i.e., long-term depression (LTD), long-term potentiation (LTP) and spinogenesis, by 17beta-estradiol, selective estrogen agonists as well as endocrine disrupters. The authors demonstrated that 1-10 nM estradiol induced rapid enhancement of LTD… CONTINUE READING
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