Rapid microglial response around amyloid pathology after systemic anti-Abeta antibody administration in PDAPP mice.

@article{KoenigsknechtTalboo2008RapidMR,
  title={Rapid microglial response around amyloid pathology after systemic anti-Abeta antibody administration in PDAPP mice.},
  author={Jessica L. Koenigsknecht-Talboo and Melanie Meyer-Luehmann and Maia Parsadanian and Monica Garcia-Alloza and Mary Beth Finn and Bradley T. Hyman and Brian J. Bacskai and David M Holtzman},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2008},
  volume={28 52},
  pages={14156-64}
}
Aggregation of amyloid-beta (Abeta) peptide in the brain in the form of neuritic plaques and cerebral amyloid angiopathy (CAA) is a key feature of Alzheimer's disease (AD). Microglial cells surround aggregated Abeta and are believed to play a role in AD pathogenesis. A therapy for AD that has entered clinical trials is the administration of anti-Abeta antibodies. One mechanism by which certain anti-Abeta antibodies have been proposed to exert their effects is via antibody-mediated microglial… CONTINUE READING

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Alzheimer’s disease: an immunohistochemical study

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