Rapid method for the isolation of the mature collagen cross-links, hydroxylysylpyridinoline and lysylpyridinoline.

@article{Ail1994RapidMF,
  title={Rapid method for the isolation of the mature collagen cross-links, hydroxylysylpyridinoline and lysylpyridinoline.},
  author={Yahya Açil and Peter K. M{\"u}ller},
  journal={Journal of chromatography. A},
  year={1994},
  volume={664 2},
  pages={183-8}
}
Hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP) are two non-reducible cross-links of mature collagen which are formed by a sequence of post-translational modifications. HP is a derivative of three residues of hydroxylysine and is present in almost all mature tissues (e.g., tendons, vessel walls, cartilage, teeth and bone). LP is a derivative of two residues of hydroxylysine and one residue of lysine and is present only in dentine and bone. Neither cross-link is found in normal human… CONTINUE READING