Rapid membrane disruption by a perforin-like protein facilitates parasite exit from host cells.

@article{Kafsack2009RapidMD,
  title={Rapid membrane disruption by a perforin-like protein facilitates parasite exit from host cells.},
  author={Bj{\"o}rn F. C. Kafsack and Janethe D O Pena and Isabelle Coppens and Sandeep Ravindran and John C Boothroyd and Vern B Carruthers},
  journal={Science},
  year={2009},
  volume={323 5913},
  pages={530-3}
}
Perforin-like proteins are expressed by many bacterial and protozoan pathogens, yet little is known about their function or mode of action. Here, we describe Toxoplasma perforin-like protein 1 (TgPLP1), a secreted perforin-like protein of the intracellular protozoan pathogen Toxoplasma gondii that displays structural features necessary for pore formation. After intracellular growth, TgPLP1-deficient parasites failed to exit normally, resulting in entrapment within host cells. We show that this… CONTINUE READING
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