Rapid mRNA-display selection of an IL-6 inhibitor using continuous-flow magnetic separation.

@article{Olson2011RapidMS,
  title={Rapid mRNA-display selection of an IL-6 inhibitor using continuous-flow magnetic separation.},
  author={Christine A. Olson and Jonathan D. Adams and Terry Torao Takahashi and Hangfei Qi and Shannon M. Howell and Ting-ting Wu and Richard W Roberts and Ren Sun and Hyongsok Tom Soh},
  journal={Angewandte Chemie},
  year={2011},
  volume={50 36},
  pages={
          8295-8
        }
}
Since the invention of hybridoma technology, methods for generating affinity reagents that bind specific target molecules have revolutionized biology and medicine. In the postgenomic era, there is a pressing need to accelerate the pace of ligand discovery to elucidate the functions of a rapidly growing number of newly characterized molecules and their modified states. Nonimmunoglobulin-based proteins such as DARPins, affibodies, and monobodies represent attractive alternatives to traditional… CONTINUE READING
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