Rapid localized spread and immunologic containment define Herpes simplex virus-2 reactivation in the human genital tract

Abstract

Herpes simplex virus-2 (HSV-2) is shed episodically, leading to occasional genital ulcers and efficient transmission. The biology explaining highly variable shedding patterns, in an infected person over time, is poorly understood. We sampled the genital tract for HSV DNA at several time intervals and concurrently at multiple sites, and derived a spatial… (More)
DOI: 10.7554/eLife.00288

Topics

12 Figures and Tables