Rapid liquid chromatographic analysis of mitoxantrone in plasma with C18 sample purification.

Abstract

A useful and rapid method for the analysis of mitoxantrone in human plasma is described. We purified the sample with a C18 Sep Pak cartridge pre-treated with methanol, water and 0.05 M ammonium phosphate (pH = 2.75). The drug and internal standard (Methylene Blue) were eluted from the cartridge with 1 M acetic acid in methanol and were separated on a 10… (More)

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Cite this paper

@article{ElYazigi1989RapidLC, title={Rapid liquid chromatographic analysis of mitoxantrone in plasma with C18 sample purification.}, author={Adnan El-Yazigi and Abba Yusuf}, journal={Journal of pharmaceutical and biomedical analysis}, year={1989}, volume={7 7}, pages={877-82} }