Rapid kinetics of tBid-induced cytochrome c and Smac/DIABLO release and mitochondrial depolarization.

@article{Madesh2002RapidKO,
  title={Rapid kinetics of tBid-induced cytochrome c and Smac/DIABLO release and mitochondrial depolarization.},
  author={Muniswamy Madesh and Bruno E. Antonsson and Srinivasa M. Srinivasula and Emad S. Alnemri and Gy{\"o}rgy Hajn{\'o}czky},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 7},
  pages={
          5651-9
        }
}
Cleavage of Bid has been shown to promote apoptosis by inducing mitochondrial membrane permeabilization with the resultant release of apoptosis-inducing proteins from the intermembrane space into the cytosol. However, direct visualization of the Bid-induced release of various proteins from the highly compartmentalized intermembrane space and the changes in the mitochondrial metabolic machinery remain elusive. Using green fluorescent protein fusion proteins and immunostaining in individual… CONTINUE READING
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cAMP inhibits bile acid-induced apoptosis by blocking caspase activation and cytochrome c release.

  • American journal of physiology. Gastrointestinal and liver physiology
  • 2002
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