Rapid kinetics of protein-nucleic acid interaction is a major component of HIV-1 nucleocapsid protein's nucleic acid chaperone function.

@article{Cruceanu2006RapidKO,
  title={Rapid kinetics of protein-nucleic acid interaction is a major component of HIV-1 nucleocapsid protein's nucleic acid chaperone function.},
  author={Margareta Cruceanu and Robert J. Gorelick and Karin Musier-Forsyth and Ioulia Rouzina and Mark Campbell Williams},
  journal={Journal of molecular biology},
  year={2006},
  volume={363 5},
  pages={867-77}
}
The nucleic acid chaperone activity of the human immunodeficiency virus type-1 (HIV-1) nucleocapsid protein (NC) plays an important role in the retroviral life cycle, in part, by facilitating numerous nucleic acid rearrangements throughout the reverse transcription process. Recent studies have identified duplex destabilization and nucleic acid aggregation as the two major components of NC's chaperone activity. In order to better understand the contribution of the functional domains of NC to… CONTINUE READING
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