Rapid isolation of IgNAR variable single-domain antibody fragments from a shark synthetic library.

@article{Shao2007RapidIO,
  title={Rapid isolation of IgNAR variable single-domain antibody fragments from a shark synthetic library.},
  author={C Y Shao and Christopher J Secombes and Andrew J. R. Porter},
  journal={Molecular immunology},
  year={2007},
  volume={44 4},
  pages={656-65}
}
The immunoglobulin isotype IgNAR (Novel Antigen Receptor) was discovered in the serum of the nurse shark (Ginglymostoma cirratum) and wobbegong shark (Orectolobus maculates) as a homodimer of two protein chains, each composed of a single variable domain (V) domain and five constant domains. The IgNAR variable domain contains an intact antigen-binding site… CONTINUE READING