Rapid ionic modifications during the aequorin-detected calcium transient in a skinned canine cardiac Purkinje cell

@article{Fabiato1985RapidIM,
  title={Rapid ionic modifications during the aequorin-detected calcium transient in a skinned canine cardiac Purkinje cell},
  author={Alexandre Fabiato},
  journal={The Journal of General Physiology},
  year={1985},
  volume={85},
  pages={189 - 246}
}
A microprocessor-controlled system of microinjections and microaspirations has been developed to change, within approximately 1 ms, the [free Ca2+] at the outer surface of the sarcoplasmic reticulum (SR) wrapped around individual myofibrils (0.3-0.4 micron radius) of a skinned canine cardiac Purkinje cell (2.5-4.5 micron overall radius) at different phases of a Ca2+ transient. Simultaneously monitoring tension and aequorin bioluminescence provided two methods for estimating the peak myoplasmic… CONTINUE READING

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The Journal of General Physiology

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