Rapid intravenous administration of granisetron prior to chemotherapy is not arythmogenic: results of a pilot study.

@article{Aapro2003RapidIA,
  title={Rapid intravenous administration of granisetron prior to chemotherapy is not arythmogenic: results of a pilot study.},
  author={Matti S. Aapro and John P. Bourke},
  journal={European journal of cancer},
  year={2003},
  volume={39 7},
  pages={927-31}
}
Patients with advanced malignancy are at an increased risk of cardiac arrhythmias, from their cancer and cardiotoxic treatments. Supportive care products co-administered should therefore not increase this risk. No clinically important cardiovascular effects are associated with the administration of granisetron over 30 s. To determine the effects of a rapid (1 s) injection of granisetron, 3 mg, on measures of cardiac repolarisation, a pilot study was performed in 17 patients undergoing… CONTINUE READING

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