Rapid intermittent movement of axonal neurofilaments observed by fluorescence photobleaching.

@article{Wang2001RapidIM,
  title={Rapid intermittent movement of axonal neurofilaments observed by fluorescence photobleaching.},
  author={Liping Wang and Anthony Brown},
  journal={Molecular biology of the cell},
  year={2001},
  volume={12 10},
  pages={
          3257-67
        }
}
Observations on naturally occurring gaps in the axonal neurofilament array of cultured neurons have demonstrated that neurofilament polymers move along axons in a rapid, intermittent, and highly asynchronous manner. In contrast, studies on axonal neurofilaments using laser photobleaching have not detected movement. Here, we describe a modified photobleaching strategy that does permit the direct observation of neurofilament movement. Axons of cultured neurons expressing GFP-tagged neurofilament… CONTINUE READING
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