Rapid initiation of repigmentation in vitiligo with Dead Sea climatotherapy in combination with pseudocatalase (PC‐KUS)

@article{Schallreuter2002RapidIO,
  title={Rapid initiation of repigmentation in vitiligo with Dead Sea climatotherapy in combination with pseudocatalase (PC‐KUS)},
  author={K. Schallreuter and Jeremy K. Moore and S. Behrens-Williams and A. Panske and M. Harari},
  journal={International Journal of Dermatology},
  year={2002},
  volume={41}
}
BACKGROUND Low catalase levels and cellular vacuolation in the epidermis of patients with vitiligo support major oxidative stress in this compartment. [...] Key Method Clinical repigmentation was documented by standardized black/white photography using non-UV coated bulbs as flashlight and by color photography. RESULTS This study on 59 patients who had vitiligo for an average time of 17 years (range 3-53 years) confirmed in vivo H(2)O(2) accumulation in mM concentrations in the epidermis of untreated patients…Expand
[Vitiligo. What is new?].
  • K. Schallreuter, M. Salem
  • Medicine
  • Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • 2010
TLDR
Considering possible genetic predisposition and /or spontaneous mutations, autoimmune reactions in the disease are put forward in the context of oxidative stress, and a review of recent and novel treatment modalities including the role of oxidativestress reduction and combined climatotherapy at the Dead Sea in a group are discussed. Expand
Vitix®– a new treatment for vitiligo?
TLDR
It has been shown that the reduction in epidermal H 2 O 2 levels induced by a low-dose, narrow-band, ultraviolet-B (UV-B)-activated pseudocatalase (PC-KUS) decreases systemic H2 O 2 stress, underlining the importance of H 2O 2 transfer from the epidersmal compartment to the vascular system. Expand
Rapid Partial Repigmentation of Vitiligo in a Young Female Adult with a Gluten-Free Diet
TLDR
Following exclusion of gluten in the diet, early and extensive repigmentation of facial lesions were noted in a young female adult of Asian ethnicity with acrofacial vitiligo and the majority of the benefits occurred within the first month and stabilized at 4 months. Expand
Topical Antioxidant and Narrowband versus Topical Combination of Calcipotriol plus BetamethathoneDipropionate and Narrowband in the Treatment of Vitiligo
Vitiligo is a specific, common, often heritable, acquired disorder characterized by well-circumscribed milky-white cutaneous macules devoid of identifiable functional melanocytes because ofExpand
Vitiligo, reactive oxygen species and T-cells.
TLDR
The present review focuses on the scientific evidence linking alterations in ROS and/or T-cells to vitiligo and speculation on the interplay, if any, between ROS and the immune system in the pathogenesis of Vitiligo. Expand
Oxidative Stress in Segmental Versus Non Segmental Vitiligo
TLDR
This study suggested that oxidative stress was present in both SV and NSV, which might open a window for several studies concerning the patients of SV and whether the oxidative stress is primary or secondary. Expand
Update on skin repigmentation therapies in vitiligo
TLDR
When vitiligo becomes refractory, surgical methods may improve depigmentation as effectively as with medical therapy; in segmental (unilateral) or long standing, non‐segmental (bilateral) stable Vitiligo, repigmentation with surgical methods is usually permanent. Expand
Vitiligo road map
TLDR
A “vitiligo road map,” consisting of basic science, clinical, and treatment components, is constructed in order to better portray the current understanding of vitiligo pathogenesis and reflect upon novel biomarkers and therapeutic targets for future research. Expand
Photo(chemo) therapy for vitiligo
  • R. Roelandts
  • Medicine
  • Photodermatology, photoimmunology & photomedicine
  • 2003
Vitiligo has always been difficult to treat. Several modes of treatment are available, but the therapeutic effect varies greatly, and rarely does one achieve complete repigmentation. One of the mostExpand
Molecular evidence that halo in Sutton’s naevus is not vitiligo
TLDR
It can be concluded that both leucodermas exercise distinct concentration-dependent H2O2 signalling in their pathomechanisms. Expand
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A topical substitution with a UVB-activated pseudocatalase can successfully remove epidermal H2O in vitiligo and leads to recovery of the oxidative damage in the epidermis and remarkable repigmentation in this disorder. Expand
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Thirty-three patients with the depigmentation disorder vitiligo were successfully treated with a new topical application of pseudocatalase, calcium and short-term UVB light exposure and no recurrence of the disease was observed during a 2 year follow-up. Expand
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A new hypothesis has been formulated for the pathogenesis of vitiligo based on a consistent reduction in levels of catalase compared to normal healthy controls of matched photo-skin types and a increase in the concentration of hydrogen peroxide in the epidermis of these patients. Expand
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The results demonstrate the presence of an imbalance in the anti-oxidant system in vitiligo melanocytes and provide further support for a free radical-mediated damage as an initial pathogenic event in melanocyte degeneration in Vitiligo. Expand
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