Rapid infusion of high-dose methotrexate resulting in enhanced penetration into cerebrospinal fluid and intensified tumor response in primary central nervous system lymphomas.

@article{Hiraga1999RapidIO,
  title={Rapid infusion of high-dose methotrexate resulting in enhanced penetration into cerebrospinal fluid and intensified tumor response in primary central nervous system lymphomas.},
  author={Sota Hiraga and Norio Arita and Takanori Ohnishi and Eiji Kohmura and Kenji Kobe Yamamoto and Yoshimasa Oku and Toshihiko Taki and Makato Sato and Katsuyuki Aozasa and Toshiki Yoshimine},
  journal={Journal of neurosurgery},
  year={1999},
  volume={91 2},
  pages={
          221-30
        }
}
OBJECT Twenty-nine nonimmunocompromised patients with primary central nervous system (CNS) lymphoma were treated with high-dose methotrexate (MTX) therapy followed by irradiation. The authors investigated the correlation of infusion schedules with MTX penetration into cerebrospinal fluid (CSF), tumor response, and survival to develop a regimen that would lead to better clinical results. METHODS In this study, 100 mg/kg MTX was administered on either a rapid (3-hour) or regular (6-hour… CONTINUE READING
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