Rapid induction of the expression of proto-oncogene fos during human monocytic differentiation.

Abstract

The differentiation into macrophages of the monocytic cell line U-937 or the monomyelocytic cell line HL-60 induced by phorbol esters is accompanied by a rapid induction of the expression of the proto-oncogene c-fos. Maximal levels of c-fos gene transcripts accumulate within 20-30 min following induction. By 2 hr, the c-fos-specific mRNA level drops 5 to 10… (More)

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Cite this paper

@article{Mitchell1985RapidIO, title={Rapid induction of the expression of proto-oncogene fos during human monocytic differentiation.}, author={R. L. Mitchell and L M Zokas and Robert D Schreiber and Inder M Verma}, journal={Cell}, year={1985}, volume={40 1}, pages={209-17} }