Rapid induction of medullary thymocyte phenotypic maturation and egress inhibition by nanomolar sphingosine 1-phosphate receptor agonist.

@article{Rosen2003RapidIO,
  title={Rapid induction of medullary thymocyte phenotypic maturation and egress inhibition by nanomolar sphingosine 1-phosphate receptor agonist.},
  author={H. K. Rosen and Christopher Alfonso and Charles D. Surh and Michael G. McHeyzer-Williams},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 19},
  pages={10907-12}
}
Only a small number of T cells generated in the thymus each day are selected to replenish the peripheral T cell pool. Much is known about thymic selection; however, little is known of the mechanisms regulating medullary maturation and the release of mature T cells into the blood. Here we demonstrate a rapid acceleration of medullary thymocyte phenotypic maturation through loss of CD69 induced by sphingosine 1-phosphate (S1P) receptor agonist. Low nanomolar agonist concentrations selectively… CONTINUE READING

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