Rapid induction of P-glycoprotein mRNA and protein expression by cytarabine in HL-60 cells.


BACKGROUND Overexpression of P-glycoprotein (P-gp), breast cancer resistance protein (BCRP) and glutathione-S-transferase pi (GSTpi) is associated with drug resistance in acute myeloid leukemia (AML). The short-term effects of drug exposure on their expression levels were investigated. MATERIALS AND METHODS HL-60 cells and drug-resistant sublines were… (More)


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