Rapid induction of B-cell lymphomas in mice carrying a human IgH/c-mycYAC

@article{Btzler1997RapidIO,
  title={Rapid induction of B-cell lymphomas in mice carrying a human IgH/c-mycYAC},
  author={Christoph B{\"u}tzler and Xiangang Zou and Andrei V. Popov and Marianne Br{\"u}ggemann},
  journal={Oncogene},
  year={1997},
  volume={14},
  pages={1383-1388}
}
Activation of the c-myc proto-oncogene by one of the immunoglobulin (Ig) loci after chromosomal translocation is a consistent feature of Burkitt's lymphoma. Different subtypes of this tumor vary in the molecular architecture of the translocation region. In most cases there are no known regulatory elements of the Ig locus neighboring the oncogene and this considerably obscures the mechanism of its deregulation. In order to assess possible oncogene activation signals, we produced an experimental… CONTINUE READING

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