Rapid induction and quantitation of morphine dependence in the rat by pellet implantation

Abstract

Four schedules of subcutaneous morphine pellet implantation were developed to render rats rapidly physically dependent on morphine. The schedules included implantation of four morphine pellets over a 3-day period (schedule 1), six morphine pellets over a 3-day period (schedule 2), six pellets over a 7-day period (schedule 3), and ten pellets over a 10-day… (More)
DOI: 10.1007/BF00426600

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