Rapid increases in peptide processing enzyme expression in hippocampal neurons.

@article{Bhat1993RapidII,
  title={Rapid increases in peptide processing enzyme expression in hippocampal neurons.},
  author={Ratan V. Bhat and Francisco A Tausk and Jay M Baraban and Richard E Mains and Betty A Eipper},
  journal={Journal of neurochemistry},
  year={1993},
  volume={61 4},
  pages={1315-22}
}
Recent studies have demonstrated that seizure activity causes a dramatic increase in neuropeptide expression in specific regions of the rat hippocampus. In this study we investigated the effect of electroconvulsive treatment (ECT) on the expression of three posttranslational processing enzymes involved in the production of many bioactive peptides from their inactive precursors. Peptidylglycine alpha-amidating monooxygenase (PAM) converts peptidylglycine substrates into alpha-amidated products… CONTINUE READING