Rapid increase of glial glutamate uptake via blockade of the protein kinase A pathway.

@article{Adolph2007RapidIO,
  title={Rapid increase of glial glutamate uptake via blockade of the protein kinase A pathway.},
  author={Oliver Adolph and Sarah K{\"o}ster and Monika R{\"a}th and Michael Georgieff and Henry U. Weigt and J{\"u}rgen Engele and Uwe Senftleben and Karl Josef F{\"o}hr},
  journal={Glia},
  year={2007},
  volume={55 16},
  pages={
          1699-707
        }
}
Glutamate is the main excitatory neurotransmitter in the vertebrate central nervous system. Removal of this transmitter from the synaptic cleft by glial and neuronal transporter systems plays an important role in terminating glutamatergic neurotransmission. The effects of different activators and blockers of PKA and PKC on glutamate uptake were studied in primary glial cells cultivated from the rat cortex using the patch-clamp recording technique and immunocytochemical methods. GF 109203X… CONTINUE READING

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