Rapid increase in non-vaccine serotypes causing invasive pneumococcal disease in England and Wales, 2000-17: a prospective national observational cohort study.

@article{Ladhani2018RapidII,
  title={Rapid increase in non-vaccine serotypes causing invasive pneumococcal disease in England and Wales, 2000-17: a prospective national observational cohort study.},
  author={Shamez N Ladhani and Sarah Neal Collins and Abdelmajid Djennad and Carmen L Sheppard and Ray Borrow and Norman K Fry and Nicholas John Abbott Andrews and Elizabeth L. Miller and Mary Elizabeth Ramsay},
  journal={The Lancet. Infectious diseases},
  year={2018},
  volume={18 4},
  pages={
          441-451
        }
}
BACKGROUND Pneumococcal conjugate vaccines (PCVs) have substantially reduced the incidence of invasive pneumococcal disease caused by vaccine serotypes; however, replacement disease with non-PCV serotypes remains a concern. We describe the population effect of the seven-valent and 13-valent PCVs (PCV7 and PCV13) on invasive pneumococcal disease in England and Wales. METHODS Using national invasive pneumococcal disease surveillance data for 2016/17, we compared incidence rate ratios (IRRs… CONTINUE READING
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