Rapid inactivation of NOS-I by lipopolysaccharide plus interferon-gamma-induced tyrosine phosphorylation.

@article{Colasanti1999RapidIO,
  title={Rapid inactivation of NOS-I by lipopolysaccharide plus interferon-gamma-induced tyrosine phosphorylation.},
  author={Marco Colasanti and Tiziana Persichini and Elisabetta Cavalieri and Cinzia Fabrizi and Sofia Mariotto and Marta Menegazzi and Giuliana Maria Lauro and Harukazu Suzuki},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 15},
  pages={9915-7}
}
Human astrocytoma T67 cells constitutively express a neuronal NO synthase (NOS-I) and, following administration of lipopolysaccharide (LPS) plus interferon-gamma (IFNgamma), an inducible NOS isoform (NOS-II). Previous results indicated that a treatment of T67 cells with the combination of LPS plus IFNgamma, by affecting NOS-I activity, also inhibited NO production in a very short time. Here, we report that under basal conditions, a NOS-I protein of about 150 kDa was weakly and partially… CONTINUE READING

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