Rapid improvement of carotid plaque echogenicity within 1 month of pioglitazone treatment in patients with acute coronary syndrome.

@article{Hirano2009RapidIO,
  title={Rapid improvement of carotid plaque echogenicity within 1 month of pioglitazone treatment in patients with acute coronary syndrome.},
  author={Mitsumasa Hirano and Takamitsu Nakamura and Yoshinobu Kitta and Toshiaki Yano and Tsuyoshi Kobayashi and Keita Sano and Daisuke Fujioka and Yukio Saito and Yasushi Kodama and Ken-ichi Kawabata and Kazuto Nakamura and Jun-ei Obata and Kiyotaka Kugiyama},
  journal={Atherosclerosis},
  year={2009},
  volume={203 2},
  pages={483-8}
}
OBJECTIVE This study examined whether pioglitazone, an agonist of peroxisome proliferator-activated receptor gamma, may stabilize vulnerable plaque with use of ultrasound evaluation of carotid artery plaque echolucency in patients with acute coronary syndrome (ACS) and type 2 diabetes mellitus (DM). METHODS AND RESULTS Treatment with pioglitazone (15 or 30mg/day, n=31) or placebo (n=30) was randomly assigned and initiated within 5 days after the onset of ACS in 61 patients with type 2 DM and… CONTINUE READING

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