Rapid impact of progesterone on the neuronal growth cone.

  title={Rapid impact of progesterone on the neuronal growth cone.},
  author={Laura Olbrich and Lisa Wessel and Ajeesh Balakrishnan-Renuka and Marion B{\"o}ing and Beate E M Brand-Saberi and Carsten Theiss},
  volume={154 10},
In the last two decades, sensory neurons and Schwann cells in the dorsal root ganglia (DRG) were shown to express the rate-limiting enzyme of the steroid synthesis, cytochrome P450 side-chain cleavage enzyme (P450scc), as well as the key enzyme of progesterone synthesis, 3β-hydroxysteroid dehydrogenase (3β-HSD). Thus, it was well justified to consider that DRG neurons similarly are able to synthesize progesterone de novo from cholesterol. Because direct progesterone effects on axonal outgrowth… CONTINUE READING