Rapid immune responses to a botulinum neurotoxin Hc subunit vaccine through in vivo targeting to antigen-presenting cells.

@article{White2011RapidIR,
  title={Rapid immune responses to a botulinum neurotoxin Hc subunit vaccine through in vivo targeting to antigen-presenting cells.},
  author={David M. White and Sabine Pellett and Mark A Jensen and William H. Tepp and Eric Arthur Johnson and Barry G. W. Arnason},
  journal={Infection and immunity},
  year={2011},
  volume={79 8},
  pages={
          3388-96
        }
}
The clostridial botulinum neurotoxins (BoNTs) are the most potent protein toxins known. The carboxyl-terminal fragment of the toxin heavy chain (Hc) has been intensively investigated as a BoNT vaccine immunogen. We sought to determine whether targeting Hc to antigen-presenting cells (APCs) could accelerate the immune responses to vaccination with BoNT serotype A (BoNT/A) Hc. To test this hypothesis, we targeted Hc to the Fc receptors for IgG (FcγRs) expressed by dendritic cells (DCs) and other… CONTINUE READING

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